GnRH –Anologues (Buserelini, Lupreide, Zoladex)

GnRH –Anologues (Buserelini, Lupreide, Zoladex) GnRH is the hormone secreted by your hypothalamus which acts on the pituitary gland to secrete FSH which stimulates the growth of follicles in the ovary. In normal cycle the pituitary depends on feedback from estridial hormone from the ovary to decide when … which bring the better ovulation. In IVF cycle the estrogen levels go up and this could trigger the LH secretion quite early in the cycle. This would make a planned egg collection difficult or impossible. To avoid this pituitary needs to be quite and to do it needs a regular supply of GnRH analogues which effectively sets down the FSH and LH production of the pituitary glands. This hormone is neither swift (sineral) nor injected intradermal (lupride). Injection started typically on the 21st day of the period and it brings on down regulation of the pituitary in around ten days. Only when we confirm that the pituitary is quite and as a result grow well, do being the hMG injections. Links – How to take your GnRH-A